Motif ID: STAT5{A,B}.p2

Z-value: 2.001


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Bhg19_v1_chr17_-_40428391_404284730.077.2e-01Click!
STAT5Ahg19_v1_chr17_+_40439564_40439564-0.057.8e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_44556163 5.450 NM_013361
 ZNF223
zinc finger protein 223
chrX_+_107288199 3.825 NM_001170553
NM_182607
 VSIG1

V-set and immunoglobulin domain containing 1

chr19_+_37709068 3.439 ZNF383
zinc finger protein 383
chr19_+_35225124 3.260 ZNF181
zinc finger protein 181
chr1_+_149754245 3.195 NM_000566
 FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr1_-_120935893 3.186 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr1_-_120935943 3.180 NM_001004340
NM_001017986
NM_001244910
 FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr9_+_130186652 3.038 NM_007135
 ZNF79
zinc finger protein 79
chr19_-_57183122 2.949 NM_001005850
 ZNF835
zinc finger protein 835
chr19_-_57988891 2.920 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr19_+_44331443 2.822 NM_181845
 ZNF283
zinc finger protein 283
chr19_+_35225095 2.770 ZNF181
zinc finger protein 181
chr2_+_63816092 2.746 MDH1
malate dehydrogenase 1, NAD (soluble)
chr18_-_43684198 2.661 NM_001001937
 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr15_+_90895476 2.594 NM_001004309
 ZNF774
zinc finger protein 774
chr19_-_40596781 2.586 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr3_-_183735617 2.557 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr19_+_44507076 2.484 NM_006300
 ZNF230
zinc finger protein 230
chr19_+_40502942 2.481 NM_178544
 ZNF546
zinc finger protein 546
chr19_-_44439410 2.476 NM_003425
 ZNF45
zinc finger protein 45
chrY_+_2709596 2.413 NM_001008
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr19_+_44455379 2.407 NM_013359
 ZNF221
zinc finger protein 221
chr2_+_95831533 2.383 ZNF2
zinc finger protein 2
chr19_+_44617510 2.369 NM_013362
 ZNF225
zinc finger protein 225
chr19_-_45004482 2.352 NM_013256
 ZNF180
zinc finger protein 180
chr19_+_58038744 2.341 ZNF549
zinc finger protein 549
chr19_-_44405934 2.336 LOC100505715
uncharacterized LOC100505715
chr19_+_44764032 2.308 NM_001207005
NM_181756
 ZNF233

zinc finger protein 233

chrY_+_2709630 2.295 RPS4Y1
ribosomal protein S4, Y-linked 1
chr2_+_63816143 2.233 NM_001199111
NM_001199112
 MDH1

malate dehydrogenase 1, NAD (soluble)

chr19_+_44576266 2.188 NM_001037813
 ZNF284
zinc finger protein 284
chr19_-_56904869 2.152 NM_144690
 ZNF582
zinc finger protein 582
chr19_+_58258160 2.134 NM_173632
 ZNF776
zinc finger protein 776
chr5_+_145317297 2.126 SH3RF2
SH3 domain containing ring finger 2
chr9_+_130186714 2.125 ZNF79
zinc finger protein 79
chr19_+_44529493 2.102 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_+_58038692 2.091 NM_001199295
NM_153263
 ZNF549

zinc finger protein 549

chr19_+_35168558 2.083 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr11_+_73357222 1.976 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_-_58326280 1.934 NM_024762
 ZNF552
zinc finger protein 552
chr2_+_95831176 1.909 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr19_+_58258189 1.907 ZNF776
zinc finger protein 776
chr1_+_153631144 1.860 NM_012437
 SNAPIN
SNAP-associated protein
chr1_+_153631193 1.834 SNAPIN
SNAP-associated protein
chr9_+_104161118 1.804 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chr4_+_84457256 1.798 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr8_-_66546394 1.789 ARMC1
armadillo repeat containing 1
chr19_-_58090071 1.777 NM_017879
 ZNF416
zinc finger protein 416
chr19_+_35225479 1.768 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr19_-_37958338 1.724 NM_152484
 ZNF569
zinc finger protein 569
chr22_-_50523853 1.714 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr6_-_27440459 1.696 NM_007149
 ZNF184
zinc finger protein 184
chr19_+_58144510 1.666 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr8_-_66546400 1.650 ARMC1
armadillo repeat containing 1
chr3_-_183543295 1.616 NM_024871
 MAP6D1
MAP6 domain containing 1
chr19_+_44488331 1.614 NM_003445
NM_198089
 ZNF155

zinc finger protein 155

chr19_+_58281049 1.579 ZNF586
zinc finger protein 586
chr10_+_86184685 1.569 FAM190B
family with sequence similarity 190, member B
chr5_-_111093251 1.524 NM_001142479
NM_001142480
NM_001142478
 C5orf13


chromosome 5 open reading frame 13


chr22_-_50523670 1.468 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_+_120740123 1.458 NM_012240
 SIRT4
sirtuin 4
chr3_-_14166370 1.453 NM_001098502
NM_144636
 CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr19_+_44598479 1.443 NM_013398
 ZNF224
zinc finger protein 224
chr19_-_58090254 1.408 ZNF416
zinc finger protein 416
chr3_-_14166228 1.402 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr19_+_58095507 1.398 NM_001010879
 ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr15_+_22833394 1.391 NM_001102610
NM_052903
 TUBGCP5

tubulin, gamma complex associated protein 5

chr3_-_14166292 1.387 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr19_+_44645708 1.383 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr7_+_99102272 1.382 NM_145102
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr19_+_58920118 1.349 ZNF584
zinc finger protein 584
chr19_+_39882018 1.261 MED29
mediator complex subunit 29
chr15_-_83735998 1.259 BTBD1
BTB (POZ) domain containing 1
chr19_-_44905754 1.257 NM_152354
 ZNF285
ZFP112
zinc finger protein 285
zinc finger protein 112 homolog (mouse)
chr19_-_58951588 1.251 NM_003433
 ZNF132
zinc finger protein 132
chr11_+_65268313 1.246 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_+_142960588 1.242 GSTK1
glutathione S-transferase kappa 1
chr19_-_58220535 1.240 NM_001085384
 ZNF154
zinc finger protein 154
chr19_+_58280996 1.178 NM_001077426
NM_001204814
NM_017652
 ZNF586


zinc finger protein 586


chr3_-_119379269 1.177 NM_022135
 POPDC2
popeye domain containing 2
chr9_-_104160876 1.167 NM_019051
 MRPL50
mitochondrial ribosomal protein L50
chr7_-_112758604 1.167 LOC401397
uncharacterized LOC401397
chr7_-_132766834 1.157 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr15_+_42066690 1.152 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr19_-_36980336 1.149 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr18_-_46987016 1.142 NM_017653
 DYM
dymeclin
chr14_+_23235730 1.140 NM_005015
 OXA1L
oxidase (cytochrome c) assembly 1-like
chr19_+_58920007 1.128 NM_173548
 ZNF584
zinc finger protein 584
chr3_-_14166246 1.116 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr8_-_66546413 1.111 NM_018120
 ARMC1
armadillo repeat containing 1
chr12_+_133657478 1.098 ZNF140
zinc finger protein 140
chr9_-_115774471 1.092 NM_001101338
 ZNF883
zinc finger protein 883
chr19_+_44645728 1.082 ZNF234
zinc finger protein 234
chr19_-_36980758 1.068 ZNF566
zinc finger protein 566
chr1_+_54519259 1.067 NM_153035
 TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr5_-_145562068 1.035 LARS
leucyl-tRNA synthetase
chr6_-_32784727 1.025 NM_002120
 HLA-DOB
major histocompatibility complex, class II, DO beta
chr2_-_142888540 1.019 LRP1B
low density lipoprotein receptor-related protein 1B
chr19_-_58514136 1.000 ZNF606
zinc finger protein 606
chr10_-_62493077 0.987 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_+_44716683 0.972 NM_182490
 ZNF227
zinc finger protein 227
chr1_+_110026452 0.963 NM_153340
 ATXN7L2
ataxin 7-like 2
chr19_+_51152634 0.959 NM_001195076
 C19orf81
chromosome 19 open reading frame 81
chr19_-_37157718 0.950 NM_153257
 ZNF461
zinc finger protein 461
chr6_+_84569394 0.946 CYB5R4
cytochrome b5 reductase 4
chr6_-_159240398 0.939 EZR
ezrin
chr7_-_112758611 0.938 LOC401397
uncharacterized LOC401397
chr19_+_45909868 0.930 CD3EAP
CD3e molecule, epsilon associated protein
chr3_+_169940246 0.922 PRKCI
protein kinase C, iota
chr7_+_99102601 0.921 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr17_+_15603046 0.918 ZNF286A
zinc finger protein 286A
chr2_-_84686585 0.918 NM_003849
 SUCLG1
succinate-CoA ligase, alpha subunit
chr6_+_84569427 0.916 CYB5R4
cytochrome b5 reductase 4
chr22_-_50523780 0.914 NM_139202
 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_+_178450775 0.912 NM_001136116
 ZNF879
zinc finger protein 879
chr5_+_80529138 0.898 NM_001099735
NM_001099736
NM_001825
 CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr7_+_99102572 0.894 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr2_-_63815761 0.891 NM_015910
 WDPCP
WD repeat containing planar cell polarity effector
chr2_+_218989997 0.888 NM_001168298
 CXCR2
chemokine (C-X-C motif) receptor 2
chr3_+_169940223 0.885 PRKCI
protein kinase C, iota
chr5_-_145562214 0.877 LARS
leucyl-tRNA synthetase
chr2_+_63815742 0.869 NM_005917
 MDH1
malate dehydrogenase 1, NAD (soluble)
chr20_-_48530275 0.862 NM_001135773
 SPATA2
spermatogenesis associated 2
chr19_-_37019169 0.845 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr19_+_58341661 0.841 NM_001204818
 LOC100293516
zinc finger protein
chr4_+_2883636 0.831 ADD1
adducin 1 (alpha)
chr19_-_37341168 0.817 NM_001242801
 ZNF790
zinc finger protein 790
chr9_+_137004913 0.817 NM_052821
 WDR5
WD repeat domain 5
chr6_-_159240367 0.805 EZR
ezrin
chr16_-_70472920 0.802 NM_006927
 ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr7_-_132766697 0.787 NM_017812
 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr6_-_159240399 0.787 EZR
ezrin
chr22_-_50523737 0.783 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr4_+_130017281 0.781 NM_001099783
 C4orf33
chromosome 4 open reading frame 33
chr12_-_46384346 0.772 SCAF11
SR-related CTD-associated factor 11
chr2_+_172290796 0.769 DCAF17
DDB1 and CUL4 associated factor 17
chr13_+_115079943 0.763 NM_001164144
NM_001164145
NM_032436
 CHAMP1


chromosome alignment maintaining phosphoprotein 1


chr16_+_53468373 0.738 RBL2
retinoblastoma-like 2 (p130)
chr19_-_44860798 0.724 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_58331067 0.720 LOC100293516
zinc finger protein
chr8_-_99306563 0.707 NM_024759
 NIPAL2
NIPA-like domain containing 2
chr17_-_48945338 0.705 NM_001243877
 TOB1
transducer of ERBB2, 1
chr3_-_151047309 0.702 NM_176894
 P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chrX_+_105412297 0.699 NM_001171020
NM_152423
 MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr4_+_86396251 0.686 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr17_-_26697293 0.681 VTN
vitronectin
chr19_-_38183135 0.679 NM_152605
 ZNF781
zinc finger protein 781
chr15_-_83735892 0.676 BTBD1
BTB (POZ) domain containing 1
chr19_-_38085646 0.673 NM_016536
 ZNF571
zinc finger protein 571
chr6_+_84569364 0.670 NM_016230
 CYB5R4
cytochrome b5 reductase 4
chr19_+_9251052 0.669 NM_001190791
NM_020933
 ZNF317

zinc finger protein 317

chr19_-_58427934 0.664 NM_152475
 ZNF417
zinc finger protein 417
chr22_-_38902300 0.663 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr17_-_39296702 0.663 NM_030976
 KRTAP4-6
keratin associated protein 4-6
chr6_-_116601085 0.659 TSPYL1
TSPY-like 1
chr17_-_3794036 0.656 NM_172206
 CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr7_+_92861652 0.642 NM_017667
NM_024553
 CCDC132

coiled-coil domain containing 132

chr15_-_83736105 0.635 NM_001011885
NM_025238
 BTBD1

BTB (POZ) domain containing 1

chr18_+_71815745 0.629 NM_014177
 TIMM21
translocase of inner mitochondrial membrane 21 homolog (yeast)
chr16_+_53468362 0.627 RBL2
retinoblastoma-like 2 (p130)
chr12_-_133532847 0.627 NM_183238
NM_001164715
 ZNF605

zinc finger protein 605

chr3_+_196466806 0.624 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_+_17378264 0.616 BABAM1
BRISC and BRCA1 A complex member 1
chr2_-_63815581 0.613 WDPCP
WD repeat containing planar cell polarity effector
chr2_-_231084600 0.613 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr19_+_17416476 0.612 NM_023937
 MRPL34
mitochondrial ribosomal protein L34
chr1_+_3773844 0.602 NM_004402
 DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr3_+_66119284 0.598 NM_173471
 SLC25A26
solute carrier family 25, member 26
chr22_-_38902344 0.596 NM_001098504
NM_006386
 DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr19_-_37406918 0.596 NM_001171979
 ZNF829
zinc finger protein 829
chr12_+_133657439 0.594 ZNF140
zinc finger protein 140
chr19_+_57946662 0.593 NM_001023561
 ZNF749
zinc finger protein 749
chr7_+_110731061 0.593 NM_001099658
NM_001099660
NM_018334
 LRRN3


leucine rich repeat neuronal 3


chr7_+_5862822 0.588


chr19_-_58446739 0.588 NM_133460
 ZNF418
zinc finger protein 418
chr12_-_46384208 0.585 SCAF11
SR-related CTD-associated factor 11
chr11_+_134123406 0.583 NM_014384
 ACAD8
acyl-CoA dehydrogenase family, member 8
chr17_-_26697310 0.582 VTN
vitronectin
chr5_+_85913762 0.581 NM_001867
 COX7C
cytochrome c oxidase subunit VIIc
chr19_+_39881950 0.579 NM_017592
 MED29
mediator complex subunit 29
chr19_-_44809126 0.575 NM_004234
 ZNF235
zinc finger protein 235
chr16_+_53468344 0.573 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr1_+_149871154 0.572 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr2_-_44223116 0.570 LRPPRC
leucine-rich PPR-motif containing
chr19_-_37341688 0.569 NM_001242800
 ZNF790
zinc finger protein 790
chr19_+_58111244 0.565 NM_020880
 ZNF530
zinc finger protein 530
chr20_-_43280359 0.563 NM_000022
 ADA
adenosine deaminase
chr22_+_20748397 0.560 NM_003426
 ZNF74
zinc finger protein 74
chr7_-_150754934 0.556 CDK5
cyclin-dependent kinase 5
chr8_+_27950583 0.555 NM_018091
 ELP3
elongation protein 3 homolog (S. cerevisiae)
chr19_+_17378148 0.546 NM_001033549
NM_014173
 BABAM1

BRISC and BRCA1 A complex member 1

chr2_-_27886443 0.543 NM_014860
 SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr17_-_39274587 0.542 NM_033059
 KRTAP4-11
keratin associated protein 4-11
chr16_+_53468406 0.531 RBL2
retinoblastoma-like 2 (p130)
chr6_+_116782555 0.529 NM_001010919
 FAM26F
family with sequence similarity 26, member F
chr20_-_33680601 0.526 NM_015638
NM_199368
 TRPC4AP

transient receptor potential cation channel, subfamily C, member 4 associated protein

chr1_+_244217283 0.526


chr2_-_44223112 0.515 LRPPRC
leucine-rich PPR-motif containing
chr16_+_53468390 0.508 RBL2
retinoblastoma-like 2 (p130)
chr2_-_241500459 0.508 ANKMY1
ankyrin repeat and MYND domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.69 1.35e-16 GO:0006355 regulation of transcription, DNA-dependent
4.52 5.17e-16 GO:0051252 regulation of RNA metabolic process
4.23 5.13e-15 GO:2000112 regulation of cellular macromolecule biosynthetic process
4.12 1.28e-14 GO:0010556 regulation of macromolecule biosynthetic process
3.93 2.06e-14 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.00 3.56e-14 GO:0010468 regulation of gene expression
3.81 5.94e-14 GO:0051171 regulation of nitrogen compound metabolic process
3.83 1.58e-13 GO:0031326 regulation of cellular biosynthetic process
3.79 2.32e-13 GO:0009889 regulation of biosynthetic process
3.04 5.52e-11 GO:0080090 regulation of primary metabolic process
3.13 5.53e-11 GO:0060255 regulation of macromolecule metabolic process
3.00 8.88e-11 GO:0031323 regulation of cellular metabolic process
2.73 2.39e-09 GO:0019222 regulation of metabolic process
1.83 1.07e-05 GO:0050794 regulation of cellular process
1.73 8.61e-05 GO:0050789 regulation of biological process
1.65 2.56e-04 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.66 1.02e-06 GO:0043231 intracellular membrane-bounded organelle
1.65 1.07e-06 GO:0043227 membrane-bounded organelle
1.57 1.54e-06 GO:0043229 intracellular organelle
1.56 1.68e-06 GO:0043226 organelle
2.01 3.52e-06 GO:0005634 nucleus
1.38 2.32e-04 GO:0044424 intracellular part
1.34 7.94e-04 GO:0005622 intracellular

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.27 2.20e-21 GO:0008270 zinc ion binding
4.64 3.66e-19 GO:0046914 transition metal ion binding
4.54 3.46e-18 GO:0003677 DNA binding
3.27 2.47e-13 GO:0003676 nucleic acid binding
2.89 3.54e-12 GO:0046872 metal ion binding
2.86 5.41e-12 GO:0043169 cation binding
2.85 5.94e-12 GO:0043167 ion binding
58.65 2.82e-02 GO:0019864 IgG binding
1.27 2.89e-02 GO:0005488 binding